No completed MLB games for October 25, 2021.
American League
| East | W | L | Pct | GB | Strk |
|---|
| Rays | 75 | 50 | .600 | - | L1 |
| Yankees | 70 | 55 | .560 | 5 | W2 |
| Red Sox | 68 | 58 | .540 | 7.5 | W2 |
| Blue Jays | 62 | 65 | .488 | 14 | W1 |
| Orioles | 61 | 65 | .484 | 14.5 | L2 |
| Central | W | L | Pct | GB | Strk |
|---|
| White Sox | 65 | 60 | .520 | - | L2 |
| Twins | 62 | 65 | .488 | 4 | W2 |
| Guardians | 61 | 65 | .484 | 4.5 | W1 |
| Tigers | 61 | 66 | .480 | 5 | L2 |
| Royals | 53 | 74 | .417 | 13 | W3 |
| West | W | L | Pct | GB | Strk |
|---|
| Astros | 63 | 63 | .500 | - | L3 |
| Rangers | 62 | 64 | .492 | 1 | W1 |
| Mariners | 59 | 67 | .468 | 4 | L1 |
| Angels | 50 | 76 | .397 | 13 | W1 |
| Athletics | 49 | 77 | .389 | 14 | L2 |
National League
| East | W | L | Pct | GB | Strk |
|---|
| Braves | 74 | 52 | .587 | - | L2 |
| Phillies | 69 | 58 | .543 | 5.5 | W5 |
| Marlins | 64 | 63 | .504 | 10.5 | L2 |
| Nationals | 60 | 67 | .472 | 14.5 | L4 |
| Mets | 57 | 70 | .449 | 17.5 | L1 |
| Central | W | L | Pct | GB | Strk |
|---|
| Brewers | 78 | 48 | .619 | - | W3 |
| Cubs | 74 | 53 | .583 | 4.5 | W2 |
| Cardinals | 65 | 62 | .512 | 13.5 | W1 |
| Pirates | 63 | 66 | .488 | 16.5 | W2 |
| Reds | 60 | 66 | .476 | 18 | L1 |
| West | W | L | Pct | GB | Strk |
|---|
| Dodgers | 76 | 51 | .598 | - | W2 |
| Padres | 68 | 59 | .535 | 8 | W1 |
| Diamondbacks | 66 | 61 | .520 | 10 | L3 |
| Giants | 51 | 74 | .408 | 24 | L2 |
| Rockies | 50 | 76 | .397 | 25.5 | L2 |
American League
| Wild Card | W | L | Pct | WCGB | Strk |
|---|
| Yankees | 70 | 55 | .560 | +8.5 | W2 |
| Red Sox | 68 | 58 | .540 | +6 | W2 |
| Rangers | 62 | 64 | .492 | - | W1 |
| Twins | 62 | 65 | .488 | 0.5 | W2 |
| Blue Jays | 62 | 65 | .488 | 0.5 | W1 |
| Guardians | 61 | 65 | .484 | 1 | W1 |
| Orioles | 61 | 65 | .484 | 1 | L2 |
| Tigers | 61 | 66 | .480 | 1.5 | L2 |
| Mariners | 59 | 67 | .468 | 3 | L1 |
| Royals | 53 | 74 | .417 | 9.5 | W3 |
| Angels | 50 | 76 | .397 | 12 | W1 |
| Athletics | 49 | 77 | .389 | 13 | L2 |
National League
| Wild Card | W | L | Pct | WCGB | Strk |
|---|
| Cubs | 74 | 53 | .583 | +6 | W2 |
| Phillies | 69 | 58 | .543 | +1 | W5 |
| Padres | 68 | 59 | .535 | - | W1 |
| Diamondbacks | 66 | 61 | .520 | 2 | L3 |
| Cardinals | 65 | 62 | .512 | 3 | W1 |
| Marlins | 64 | 63 | .504 | 4 | L2 |
| Pirates | 63 | 66 | .488 | 6 | W2 |
| Reds | 60 | 66 | .476 | 7.5 | L1 |
| Nationals | 60 | 67 | .472 | 8 | L4 |
| Mets | 57 | 70 | .449 | 11 | L1 |
| Giants | 51 | 74 | .408 | 16 | L2 |
| Rockies | 50 | 76 | .397 | 17.5 | L2 |